Well-known macroscopic asymmetries are the Yakovlevian torque as well as the larger size of the left planum temporale 1, 2, 3, 4. These anatomical asymmetries can be found both at the macroscopic and at the microscopic level. Although its generally symmetrical shape, structural and functional asymmetries appear to be important features of the brain organization. ![]() The study of the human brain compels us to challenge many seeming inconsistencies and counter-intuitive observations. These findings show that MHC can be an insightful tool to study how the hemispheres functionally interact during task and rest conditions. Two main differences were found from rest to task: (i) regions known to be characterized by global hubness are more similar than regions displaying local hubness and (ii) medial areas are characterized by a higher degree of homotopic connectivity, while lateral areas appear to decrease their degree of homotopic connectivity during task performance. ![]() The comparison between the two techniques reveals their general similarity, but also highlights regional differences associated with how HC varies from task to rest. Since functional connectivity can be revealed also in a meta-analytical fashion using co-activations, here we propose to calculate the meta-analytic homotopic connectivity (MHC) as the meta-analytic counterpart of the VMHC. ![]() The voxel-mirrored homotopic connectivity (VMHC) is a technique devised to enquire this pattern of brain organization, based on resting state functional connectivity. It can exhibit a marked and functionally relevant spatial variability, and can be perturbed by several pathological conditions. Homotopic connectivity (HC) is the connectivity between mirror areas of the brain hemispheres.
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